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KMID : 0043319980210030353
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Archives of Pharmacal Research
1998 Volume.21 No. 3 p.353 ~ p.356
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Boron Trifluoride Etherate on Silica-A Modified Lewis Acid Reagent (VII). Antitumor Activity of Cannabigerol Against Human Oral Epitheloid Carcinoma Cells
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Baek Seung-Hwa
Kim Young-Ok
Kwag Jung-Suk
Choi Kyw-Eun
Jung Woo-Young
Han Du-Seok
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Abstract
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Geraniol (1), olivetol (2), cannabinoids (3 and 4) and 5-fluorouracil (5) were tested for their growth inhibitory effects against human oral epitheloid carcinoma cell lines (KB) and NIH 3T3 fibrobalsts using two different 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and sulforhodamine B protein (SRB) assay. Cannabigerol (3) exhibited the highest growth-inhibitory activity against the cancer cell lines.
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KEYWORD
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Cannabinoid, 5-Fluorouracil, Cannabigerol, Antitumor activity, Human oral epitheloid carcinoma cell, MTT assay, SRB assay
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